Re: sequential PKPD modeling

From: "Liping (CD) Zhang" liping.zhang3@bms.com Subject: Re: [NMusers] sequential PKPD modeling Date: Thu, 26 Oct 2006 15:54:50 -0400 Hi, Jim! "simultaneous analysis of PKPD data is a better analysis especially for the sparse PK data, because the PD data can support PK data analysis. " Simultaneous analysis of PKPD data is a better method because it naturally follows the maximal likelihood theory. PD's support for PK analysis is not for granted: a misspecified PD model could distorted PK model. For references, see Bennett and Wakefield, 2001, Biometrics, 57:803-12, and Zhang et al, 2003, JPP: 405-16. I assume you've had data from A alone, and data from A and B administrated, and when you model A+B PK/PD simultaneously, you get a large Cl for A than the one from A alone? (I could only think of this case, to support your statement "B was shown to increase the Cl of A"). If that is the case, doing the PK modeling on A using the data A+B, and then comparing the estimated Cl with estimated Cl from A alone, wouldn't that provide an answer? best regards, Liping