sequential PKPD modeling

From: Xuemin Jiang Date: October 26, 2006 technical Source: cognigencorp.com
From: "Jiang, Xuemin" xjiang1@medicine.bsd.uchicago.edu Subject: [NMusers] sequential PKPD modeling Date: Thu, 26 Oct 2006 09:53:07 -0500 Dear NONMEM users, I am developing PKPD modeling of a drug which can increase blood pressure (Drug A) simultaneously. A co-administered drug (Drug B) which can decrease blood pressure was found to increase the CL of Drug A. I am wondering whether the simultaneous PKPD modeling is able to confirm the finding or a sequential PKPD modeling need to be used in this case. Thanks Jim Jiang

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Oct 26, 2006 Xuemin Jiang sequential PKPD modeling
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