RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
From: Chuanpu.Hu@sanofi-aventis.com
Subject: RE: [NMusers] WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Date: Wed, 27 Sep 2006 09:25:53 -0400
Hi Mats,
Sorry for not interpreting you correctly - thank you for clearifying. I
agree with your second point, and I generally don't go about deleting
outliers. My point was that if one does delete outliers, then the impact
should be assessed. In particular, I have seen "assessments" been reported
with changes in -2LL, which I think is misleading.
Regarding your first point, I think sometimes in practice a "good job" is
not done, for various reasons. For example, we know that dosing or sample
collection times are inexact in phase III trials. Modeling can be attempted
fot this, but not easilly. Could you comment on searching and dealing with
outliers in this situation.
Best regards,
Chuanpu