RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION

From: Alan Xiao Date: September 26, 2006 technical Source: cognigencorp.com
From: "Xiao, Alan" alan_xiao@merck.com Subject: RE: [NMusers] WRES AND OUTLIER IDENTIFICATION/EXCLUSION Date: Tue, 26 Sep 2006 10:37:08 -0400 I think the key is when to exclude the "outliers". If they are excluded at the beginning, you might lose some important information about your drug (and consequently important findings) as Mike mentioned below. If they are excluded after you got a final model and you want to refine the final model with the exclusion, you then lose much less information - you can not really well characterize the lost part anyway since your model can not capture them either because they are simply data errors or non-representativeness for a new population or other reasons you can imagine, although you still need an interpretation about the "outliers". In this case, your refined final model might be more reliable to data which are representative, but not covering the outliers. Appropriate documentation and interpretation (and implication) are very important. Alan
Sep 25, 2006 Niyi Adedokun WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 25, 2006 William Bachman RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 25, 2006 Nick Holford RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 25, 2006 Mark Sale RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 William Bachman RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 Andrew Hooker RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 Michael Fossler RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 Leonid Gibiansky RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 Michael Fossler RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 Mats Karlsson RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 Niyi Adedokun RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 Alan Xiao RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 Leonid Gibiansky RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 Michael Fossler RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 Chuanpu Hu RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 26, 2006 Mats Karlsson RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 27, 2006 Sima Sadray RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 27, 2006 Partha Nandy RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 27, 2006 Chuanpu Hu RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 27, 2006 Kenneth Kowalski RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 27, 2006 Mats Karlsson RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 28, 2006 Jeroen Elassaiss-Schaap RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 28, 2006 Kenneth Kowalski RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 29, 2006 Mats Karlsson RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 29, 2006 Kenneth Kowalski RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Sep 30, 2006 Mats Karlsson RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Oct 01, 2006 Nick Holford RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Oct 02, 2006 Mats Karlsson RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Oct 02, 2006 Nick Holford RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Oct 02, 2006 Mats Karlsson RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Oct 02, 2006 Nick Holford Re: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Oct 02, 2006 Kenneth Kowalski RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Oct 02, 2006 Kenneth Kowalski RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Oct 03, 2006 Kenneth Kowalski RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
Oct 03, 2006 Kenneth Kowalski RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION