RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION

From: Michael.J.Fossler@gsk.com Subject: RE: [NMusers] WRES AND OUTLIER IDENTIFICATION/EXCLUSION Date: Tue, 26 Sep 2006 11:37:30 -0400 I routinely use the varying sigma residual model and usually see a great improvement in the fit. As Mats points out, it allows one to side-step the issue of data exclusion. Mike ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Michael J. Fossler, Pharm. D., Ph. D., F.C.P. Director Clinical Pharmacokinetics, Modeling & Simulation GlaxoSmithKline (610) 270 - 4797 FAX: (610) 270-5598 Cell: (443) 350-1194 Michael_J_Fossler@gsk.com ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~