Re: likelihood model for missing SEX data

From: "Stephen Duffull" stephen.duffull@stonebow.otago.ac.nz Subject: Re: [NMusers] likelihood model for missing SEX data Date: 9 July 2006 23:14 Hi Kristin wrote: > possible. Yet I wonder what method would be best if no other > covariates > are available and if the effect of SEX on CL is substantial. I am > interested in your suggestion to use individual probabilities and a > linear covariate model. I realise the thread is really relevant to any binary covariate, but biologically why would SEX be expected to be an important covariate? Once size has been accounted for then females are essentially in a pharmacokinetic sense smaller males. Reviews have found only minimal differences between males and females once body size (and more specifically body composition) has been taken into account. Steve ========================== Professor Stephen Duffull Chair of Clinical Pharmacy School of Pharmacy University of Otago PO Box 913 Dunedin New Zealand E: stephen.duffull@stonebow.otago.ac.nz P: +64 3 479 5044 F: +64 3 479 7034