RE: Covariate models of genetic polymorphisms

From: "Tham Lai San, PHCV2" phcv2@nus.edu.sg Subject: RE: [NMusers] Covariate models of genetic polymorphisms Date: Mon, 10 Jul 2006 08:18:53 +0800 Dear Mark, Bill and David, Being a relatively inexperienced NM user coming from an island where few people speak the same lingo, you advice is very much appreciated. I am investigating the SNP polymorphims for a bunch of transciptional regulators of CYP450, so to be specific, Mark is right about calling them receptors rather than genes. This is a preliminary screening exercise to see if my hypothesis holds because I am not examining the effect of CYP polymorphims on CL but effect of receptor polymorphims on CYP expression. However, I did notice while screening through the polymorphisms of individual SNPs that using a binary covariate for mutants is not as good as separating heterozygous from homzygous mutants. Meanwhile, still working through the permutations, via the brute force method! :-) Lai-San Tham, PharmD Department of Hematology-Oncology National University Hospital, Singapore _______________________________________________________