Covariate models of genetic polymorphisms

From: "Tham Lai San, PHCV2" phcv2@nus.edu.sg Subject: [NMusers] Covariate models of genetic polymorphisms Date: Thu, 6 Jul 2006 15:37:25 +0800 Dear Colleagues, I am trying to model the variants of a few genes as covariates. On their own, when modelled as GRPCL=POP_CL*SizeDescriptor*FGene1 where by the Fgene1(theta) has 3 values for wild type, heterozygous mutant and homozygous mutant respectively, most have shown some functional effect on CL. Would like to know if anybody has some prior experience putting in multiple genes as covariates into the model and how best to approach this? E.g. GRPCL=POP_CL*SizeDescriptor*FGene1+FGene2 or GRPCL=POP_CL*SizeDescriptor*FGene1*FGene2? What if the genes are also known to cross-talk? Best Regards, Lai San Tham