Simulation of Steady state concentration of Phenytoin

From: varun goel varun_goel_9@yahoo.com Subject: [NMusers] Simulation of Steady state concentration of Phenytoin Date: Sun, 11 Jun 2006 14:14:39 -0700 (PDT) Dear All, I am trying to simulate steady state concentrations of phenytoin with TDM in Nonmem. I am simulating Vmax and Km values according to published literature. However I get in trouble while adjusting for dose. As I desire the concentrations levels to lie in the window of 5-25 ug/mL. I manually have to change the dosing records for concetrations that are low or go very high (sometimes enormous concentrations when Vmax is lower than dose). I am looking for suggestions regarding making it more automated in Nonmem. Any references or suggestions on this matter is highly appreciated. Thanks Varun Goel Graduate Student Experimantal and Clinical Pharmacology University of Minnesota, Minneapolis, MN