RE: Need help

From: "Bachman, William (MYD)" bachmanw@iconus.com Subject: RE: [NMusers] Need help Date: Thu, May 19, 2005 10:14 am At first glance, your control stream and data file look OK. What I would do as a diagnostic, in my opinion, is to use: "$ESTIMATION MAXEVALS=9999 PRINT=1 MSF=runX.msf METHOD=0 NOABORT POSTHOC " this allows creation of an INTER file that generates output for every iteration that can be read to determine that NONMEM is running and doing something in case the problem is just very slow and not just sitting there "spinning". Secondly, it's always a good idea to create the msf file and costs you nothing timewise. Your PK model is sufficiently simple that it should not be slow unless your data set is HUMONGOUS. Also, simplify your $ERROR model, just to see if a basic model works: $ERROR Y=F + F*EPS(1) IPRED=F $SIGMA 1.0