Re: Need help

From: "Nick Holford" n.holford@auckland.ac.nz Subject: Re: [NMusers] Need help Date: Thu, May 19, 2005 6:39 pm It is possible to determine that NONMEM is producing output by examining the file time and date on OUTPUT (and other files). This can be done with or without creating an INTER file. If the timestamp changes then NONMEM is producing output. An added benefit of having the INTER file is that it lets you examine the current parameter estimates in a user intelligible format (unlike the transformed and unintelligible values provided in the usual iteration monitoring output). One puzzling feature for those not familiar with the use of INTER is that this file is deleted as soon as NONMEM finishes. By default you can only examine the results while NONMEM is actually running. This less than fully helpful behaviour can be changed by commenting out the following line in the NONMEM CFILES fortran source code file and then recompiling NONMEM. e.g. Change from CLOSE (UN(28),STATUS='DELETE') to C CLOSE (UN(28),STATUS='DELETE') I also find it helpful to change the name of the file to INTER.txt so that I can open it easily using the Windows Explorer. This is done by changing the second line below in the NONMEM BLKDAT fortran source file and recompiling NONMEM. Change from: DATA FNSTP,FNINT,FNERR,FNINTR,FNULL 1/'nul','con','PRDERR','INTER','nul'/ to: DATA FNSTP,FNINT,FNERR,FNINTR,FNULL 1/'nul','con','PRDERR','INTER.txt','nul'/ Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/ _______________________________________________________