RE: simulation of dose escalation study

From: "Tsai, Max" max.tsai@spcorp.com Subject: RE: [NMusers] simulation of dose escalation study Date: Fri, April 15, 2005 8:07 am Anthe, I have encountered a similar issue recently. There are two approaches that I have taken. The first approach utilizes a programming language (I used SAS) to create all of the control streams to be run in your simulation. Using a "random" number generator, specify the random value as part of a larger character string (i.e. control stream) in SAS so that each control stream will have a different seed value. The second approach uses the subproblem option of the simulation statement in NONMEM. In your case, subproblems=200. This should provide different values for each replicated study. You may need to use SAS or some other software to help you sort through what will be a large output table. Hope this helps. -Max