NONMEM questions

From: Ping Ji ping.ji@bms.com Subject: [NMusers] NONMEM questions Date: Fri, 18 Mar 2005 11:53:14 -0500 Dear users, I am new to this community. I am trying to fit multiple dose data from healthy subjects (TYPE=0) and patients (TYPE=1). I use two-compartment with zero- and first-order absorption and absorption lag time in patients. Shown below is the control file. My problem is that output is always "minimization terminated". Can anyone help me out to see what is the problem? > $PROB MAD&POC > $INPUT C ID AMT RATE TIME DV EVID TYPE > $DATA full-data-set.csv IGNORE=C > $SUBROUTINE ADVAN4 TRANS4 > $PK > > IF (TYPE.EQ.0) TVCL=THETA(1) > IF (TYPE.EQ.1) TVCL=THETA(2) > CL=TVCL*EXP(ETA(1)) > > D1=THETA(3) > > IF(TYPE.EQ.0) TVV2=THETA(4) > IF (TYPE.EQ.1) TVV2=THETA(5) > V2=TVV2*EXP(ETA(2)) > > Q=THETA(6) > > V3=THETA(7) > > KA=THETA(8)*EXP(ETA(3)) > > IF(TYPE.EQ.1) ALAG1=THETA(9) > S2=V2/1000 > S3=V3/1000 > > $THETA (0,10) (0, 10) (0,1) (0,20) (0,20) (0,4) (0,160) (0,0.3) (0,0.1) > $OMEGA BLOCK(2) > 0.1 0.05 0.2 > $OMEGA 0.5 > $ERROR > IPRE=F > Y1=F*(1+EPS(1))+EPS(2) > Y2=F*(1+EPS(1))+EPS(3) > Q1=0 > Q2=0 > IF (TYPE.EQ.0) Q1=1 > IF (TYPE.EQ.1) Q2=1 > Y=Q1*Y1+Q2*Y2 > > > $SIGMA 0.4 10 10 > $ESTIMATION NOABORT SIG=6 MAX=9999 PRINT=10 > $TABLE ID TIME IPRE DV PRED EVID TYPE