Re: Number of subject and population PK/PD modeling

From: daren.j.austin@gsk.com Subject: Re: [NMusers] Number of subject and population PK/PD modeling Date: Thu, January 27, 2005 9:40 am Gordi, I've used pop-pk for toxicokinetic studies for both dogs and rats. This approach has been used predominantly where data was censored (BQL) in some animals at late time points. The population method correctly uses all of the data without imputation and will, in general provide a more accurate (higher) estimate of AUC(0-inf). These analyses were not done prospectively. Do bear in mind that the variability is likely to be low, even in six subjects, and certainly lower than you will be used to in humans. Kind regards, Daren Dr. Daren J. Austin Director, CPK/Modelling & Simulation Clinical Pharmacology Discovery Medicine GlaxoSmithKline R&D Work: 7-711 2073 or +44 (0) 20 8966 2073 Mobile: 07712 670097 ________________________ voli i cervi volanti, guidi le bici _______________________________________________________