RE: Model estimate of dose

From: "Bachman, William (MYD)" bachmanw@iconus.com Subject: RE: [NMusers] Model estimate of dose Date: Tue, December 7, 2004 10:57 am Maybe I'm missed something in the previous discussions but I still think Nick's explanation still holds. Put your unit dose in the data file and estimate Fn. e.g. if you assume, dose goes to CMT=1 $INPUT C ID TIME DV AMT CMT $SUBROUTINE ADVAN2 TRANS2 $PK TVCL=THETA(1) CL=TVCL*EXP(ETA(1)) TVV=THETA(2) V=TVV*EXP(ETA(2)) TVKA=THETA(3) KA=TVKA*EXP(ETA(3)) S2=V TVF1=THETA(4) F1=TVF1*EXP(ETA(4)) F1 is then the estimated dose. (appropriate constraints of parameter estimates may be needed, but, there is nothing that inherently dicates F1 can't be greater than 1) Bill