RE: Model estimate of dose

From: Johan.Rosenborg@astrazeneca.com Subject: RE: [NMusers] Model estimate of dose Date: Thu, 9 Dec 2004 9:28 am Bill, Thank you for your contribution on this issue, too! Indeed, the use of an unconstrained value of F is a way to moderate the measured dose value. However, I would like to balance two processes using rate constants, absorption into the systemic circulation and extravascular elimination from the airways, and at the same time try to avoid the constraint of a fixed dose value since I have data on the amount of tracer in the lungs. In that case isn't it better not to use the bioavailability factor? / Johan >> Johan Rosenborg >> AstraZeneca R&D Lund >> Experimental Medicine, S-221 87 Lund, Sweden >> Tel: +46 46 33 65 99 Fax: +46 46 33 71 91 >> E-mail: johan.rosenborg@astrazeneca.com _______________________________________________________