Model estimate of dose

From: Johan.Rosenborg@astrazeneca.com Subject: [NMusers] Model estimate of dose Date: Mon, November 29, 2004 5:41 am Dear NMusers, I have a dataset with observations both at site of absorption and in plasma. The system must be initialized with a bolus dose in the depot compartment at time zero to establish the initial condition. I would like to use the data at the absorption site to estimate the actual dose given; A(depot compartment)=THETA(X) at time zero - does anyone know how to do this? / Johan > Johan Rosenborg > AstraZeneca R&D Lund > Experimental Medicine, S-221 87 Lund, Sweden > Tel: +46 46 33 65 99 Fax: +46 46 33 71 91 > E-mail: johan.rosenborg@astrazeneca.com