RE: Simulation problem

From: "Nick Holford" Subject: RE: [NMusers] Simulation problem Date: Mon, November 22, 2004 3:17 pm Manoj, Simulation and estimation are NOT simultaneous. NONMEM first simulates values and creates a new data set that replaces the DV values in the original input data set. Then this modified data set is used for estimation using the simulated DV values. As I said earlier it is not necessary to fix parameter values for the simulation step. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/