RE: Simulation problem

From: "Nick Holford" n.holford@auckland.ac.nz Subject: RE: [NMusers] Simulation problem Date: Mon, November 22, 2004 2:05 pm Manoj, First of all if you want help please do not say "its not running so obviously there is something wrong that I am doing" without giving details of what goes wrong!! I cannot see anything obviously wrong with your code for simulation but without any clues to the error I havent looked very closely. If you are doing $SIM ONLYSIM there is no need to add FIX to all the parameter records. Simulation implicitly means that the parameter remain fixed at their original values. Simulation and estimation can be done at the same time by including both a $SIM and a $EST record in the control stream and removing ONLYSIMULATION from the $SIM record. If you remove all $OMEGA records then NM-TRAN does not understand about $SIGMA because NONMEM only recognizes the second level of random effects implied by $SIGMA if there are $OMEGA records for the first level. If you remove all $OMEGA records and references to ETA, change $SIGMA to $OMEGA and change ERR to ETA then NM-TRAN will accept this as a non-population problem. However, the simplest way to simulate an individual is to fix all OMEGA estimates to zero. This fools NM-TRAN into thinking you are doing a population problem. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/