NONMEM troubleshoot

From: "Pravin Jadhav" pravinj@gmail.com Subject: [NMusers] NONMEM troubleshoot Date: Tue, October 19, 2004 11:11 pm Hello all, I am getting some strange behavior while running one problem set. I am performing sequential PK-PD modeling for a drug I am working on. The data consist of 99 patients studied over 3 periods with a total 36000 PD observations. Recently, I had to recompile NONMEM to run this problem. I ran a base model and got results closer to my expectations. After updating the model, I run into this strange problem:- NONMEM seems to run thr' its iterations (as I see on my screen), but at one point gets stuck FOREVER. It looks like it was closer to the minimum (guess based on a little change in the OFV among iterations, which was also less than the OFV for the base model). It may be a local minimum but I tried constraining the parameters within realistic range w/o success. I know sounds very vague but I have no better explanation. I just want to know where to look for with such kind of troubleshooting. BTW, I am running METH=0 and not performing $COV step. Thanks, Pravin -- Pravin Jadhav Graduate Student Department of Pharmaceutics MCV/Virginia Commonwealth University DPE1/CDER/OCPB/Food and Drug Administration Phone: (301) 594-2623 Fax: (301) 480-3212