RE: NONMEM troubleshoot

From: Chuanpu.Hu@sanofi-synthelabo.com Subject: RE: [NMusers] NONMEM troubleshoot Date: Thu, October 21, 2004 9:25 am Dear Pravin, I have had NONMEM stuck with "normal" PK data, as others did too. Whether it is near a local minimum or not does not seem to matter. It happens very rarely and changing initial estimates always solved the problem. It sounds like your problem is more difficult, but just wondering whether you have tried it. By the way, do the initial estimates corresponding to reasonable goodness of fit? Good luck, Chuanpu ------------------------------------------------------------------- Chuanpu Hu, Ph.D. Assistant Director, Biostatistics Sanofi-Synthelabo Research 9 Great Valley Parkway Malvern, PA 19355-1304 Tel: (610) 889-6774 Fax: (610) 889-6932