RE: allometric scaling

From: "Nick Holford" n.holford@auckland.ac.nz Subject: RE: [NMusers] allometric scaling Date: Mon, October 18, 2004 4:47 am Frederike, YES -- I would consider allometric scaling of clearance and volume to be the correct model a priori to account for differences between the infants due to size. I would then look for developmental changes in renal function related to post-gestational age and changes in volume related to post-natal age. This is because I expect renal function will increase with age but volume (per kg) is unlikely to change much in utero. However, after birth most babies lose a lot of body water and this can cause substantial decreases in volume especially for drugs with Vd closely linked to body water volume e.g. aminoglycosides. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/ _______________________________________________________