RE: covariates
From: drfreedman@drfreedmaninc.com
Subject: RE: [NMusers] covariates
Date: Thu, September 16, 2004 8:33 am
Nick and Renee
Please note there can additional causes of weight dependence.
If, for example, a concomitant medication dosed by BSA
impacts Emax by killing receptors, I would expect Emax to
depend somewhat on WT. If this additional medication also
modulates CL, then CL may, in principle, show WT dependence
additional to allometric scaling. If significant weight loss
occurs throughout the study and admission weight is the WT
covariable, I would also expect some residual dependence of
OFV on WT.
Regards
Immanuel Freedman, PhD, MIEEE
(619) 884-1347