RE: covariates

From: "Nick Holford" Subject: RE: [NMusers] covariates Date: Thu, September 16, 2004 11:10 pm Immanuel, I agree there may be other ways that WT may influence PK parameters. But I think it's important to get the allometric component sorted out before searching for empirical relationships. It's not so clear if within subject variability in WT would vary allometrically especially if WT changes are due to disease progression. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/