RE: Interoccassion variability and Auto-induction model

From: Gastonguay, Marc" marcg@metrumrg.com Subject: RE: [NMusers] Interoccassion variability and Auto-induction model Date: Mon, September 13, 2004 9:57 am Hello Partha, Given an adequate experimental design and an appropriate auto-induction model, you should be able to separate the systematic time-dependent increases in clearance due to auto-induction, from the non-systematic random fluctuations in clearance across sampling occasions. You can check the precision (reliability) of the estimates by obtaining some measure of estimation uncertainty (NONMEM standard errors, bootstrap CI, etc.). The reliability of the model for your intended purposes could be explored by performing a predictive check (Monte Carlo simulations of the original data design) using models with/without IOV and comparing the predictive performance based on a characteristic of interest from the observed data (e.g. AUC, Cmin, Cavg etc. on each occasion). Marc ========================== Marc R. Gastonguay, Ph.D. Metrum Research Group LLC 15 Ensign Drive Avon, CT 06001 T: 860.670.0744 F: 860.760.6014 E: marcg@metrumrg.com www.metrumrg.com _______________________________________________________