Interoccassion variability and Auto-induction model

From: "Partha Nandy" partha.nandy@bms.com Subject: [NMusers] Interoccassion variability and Auto-induction model Date: Fri, September 10, 2004 10:37 am Hi All, I have a question for the group, and any help/suggestion that you can provide is greatly appreciated. If a drug exhibits auto-induction, how feasible is it to estimate Interoccassion variability, and how reliable are the estimates in such a situation? I am not sure whether one can estimate IOV in this case. Does anyone have prior experience with such a situation? Thanks Partha Partha Nandy Clinical Discovery-BMS