RE: Interoccassion variability and Auto-induction model

From: "Gordi, Toufigh" Toufigh.Gordi@cvt.com Subject: RE: [NMusers] Interoccassion variability and Auto-induction model Date: Fri, September 10, 2004 1:54 pm Dear Partha, I guess the answer depends on how you model the auto-induction and what data you have. We have applied a semi-physiological model to data on the auto-induction of artemisinin given orally. The model includes estimations of IOV on ka and time-lag. The induction is modeled as increase in the enzyme amounts, which increase the extraction ratio of the compound, thereby affecting its F and CL. The manuscript is sent to BJCP and is under review. I would be more than happy to provide you with the control stream. Best wishes, Toufigh Gordi