Re: Time of day as a covariate

From: Nick Holford - n.holford@auckland.ac.nz Subject: Re: [NMusers] Time of day as a covariate Date: 2/9/2004 8:47 PM Pete, What do you mean by 'important'? IMHO a P value has no merit by itself to justify a labelling claim. What is the magnitude of the effect on V1 in relation to time? Is the clinical benefit or adverse effects related to concentrations e.g. peak conc, that might be strongly influenced by variation in V1? Is there a clinically relevant reduction in the between subject variability of V1 when you account for time of day? What is the route of adminstration and what kind of subjects? Healthies? Patients? What kind of disease? Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/