Time of day as a covariate

From: "Bonate, Peter" - pbonate@ilexonc.com Subject: [NMusers] Time of day as a covariate Date: 2/9/2004 3:53 PM Hi, everyone. I am working on a drug where the time of day the drug was administered is important as a covariate for V1 (p = 0.003). I have a few ideas for why this may be happening, but I'd like to hear from anyone who might have their own opinion about possible mechanisms. More importantly is how to report this unusual finding. For instance, how might Vdss be reported in the product label. Would you even try to put this in the label? Any thoughts on how to present this data would be helpful. Actually, any thoughts on this at all would be appreciated. This is a Pandora's box I wish I had never opened. Thanks alot everyone, pete Peter L. Bonate, PhD, FCP Director, Pharmacokinetics ILEX Oncology 4545 Horizon Hill Blvd San Antonio, TX 78229 phone: 210-949-8662 fax: 210-949-8219 email: pbonate@ilexonc.com