RE: Fixed elements within a block covariance matrix

From: Stephen Duffull Date: January 13, 2004 technical Source: cognigencorp.com
From: Steve Duffull - sduffull@pharmacy.uq.edu.au Subject: RE: [NMusers] Fixed elements within a block covariance matrix Date: 1/13/2004 5:22 PM Vicente You are right - X11 and X22 will be implicitly correlated through the other covariance structure. However in the NONMEM OMEGA statement below they will not be explicitly correlated. Without specifically doing simulations to check this - I would guess that the implicit correlation would hold (to some extent) - even when you fix the explicit covariance to zero in the OMEGA block. I would be interested to know this too, can someone advise me on this? Steve