RE: Fixed elements within a block covariance matrix
From: Steve Duffull - sduffull@pharmacy.uq.edu.au
Subject: RE: [NMusers] Fixed elements within a block covariance matrix
Date: 1/13/2004 5:22 PM
Vicente
You are right - X11 and X22 will be implicitly correlated through the other
covariance structure. However in the NONMEM OMEGA statement below they will
not be explicitly correlated. Without specifically doing simulations to check
this - I would guess that the implicit correlation would hold (to some
extent) - even when you fix the explicit covariance to zero in the OMEGA block.
I would be interested to know this too, can someone advise me on this?
Steve