RE: Fixed elements within a block covariance matrix

From: Vladimir Piotrovskij Date: January 13, 2004 technical Source: cognigencorp.com
From: Vladimir Piotrovsky, Ph.D. - VPIOTROV@PRDBE.jnj.com Subject: RE: [NMusers] Fixed elements within a block covariance matrix Date: 1/13/2004 9:27 AM Pete, You can try to change the indices of ETAs to come up with the matrix [X11 X21 X22 0 X32 X33] In this case you can fix the lower left element to zero. Best regards, Vladimir ----------------------------------------------------------------- Vladimir Piotrovsky, Ph.D. Research Fellow, Advanced PK-PD Modeling & Simulation Global Clinical Pharmacokinetics and Clinical Pharmacology (ext. 5463/151) Johnson & Johnson Pharmaceutical Research & Development Turnhoutseweg 30 B-2340 Beerse Belgium