Fixed elements within a block covariance matrix

From: Peter Bonate Date: January 13, 2004 technical Source: cognigencorp.com
From:Peter L. Bonate - pbonate@ilexonc.com Subject:[NMusers] Fixed elements within a block covariance matrix Date: 1/13/2004 8:50 AM Dear all, I need to generate a covariance matrix of the following: [X11 0 X22 X31 X32 X33] where X12 is fixed to zero and all other elements are non-zero. Is there any easy way to do this? Thanks. Peter L. Bonate, PhD, FCP Director, Pharmacokinetics ILEX Oncology 4545 Horizon Hill Blvd San Antonio, TX 78229 phone: 210-949-8662 fax: 210-949-8219 email: pbonate@ilexonc.com