Re: Scaling of pharmacokinetics in peds

From: Nick Holford - n.holford@auckland.ac.nz Subject: Re: [NMusers] Scaling of pharmacokinetics in peds Date: 12/19/2003 3:00 AM Paul, Fine in theory but in practice I expect it would require a wide range of weights plus doses and intensive sampling to expect to be able to distinguish any departure from the theoretical expectation of 0.75 for the allometric exponent. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/