How to do simulation?

From: YZ [mailto:zhang.239@osu.edu] Subject: [NMusers] How to do simulation? Date: Thursday, November 06, 2003 1:57 PM Dear All, I am working on an oral compound that can be described by one compartment model with 1st order absorption and 1st order elimination. Preclinical PK results show that most of the absorbed dose was metabolized to one metabolite, and unchanged drug was excreted in urine, bile and feces. The clinical results show that the plasma concentration of the metabolite is proportional to its parent compound. But the AUC ratio between the metabolite and parent compound was variant with time (different day). I built a model to describe this phenomenon. My question is how to do the simulation to the metabolite in NONMEM? I can get an output table with DV and MET and also PRED for the DV, but I don't know how to output the predicted value for the metabolite. Thanks. Yilong Zhang, Ph.D. Postdoctoral Researcher College of Pharmacy The Ohio State University