RE: How to do simulation?
From: "YZ"
Subject: RE: [NMusers] How to do simulation?
Date: Thu, November 6, 2003 4:15 pm
Dear All:
Following is the model I wrote. Please let me know how to change it to get the
simulation for both parent compound and metabolite. Thanks a lot.
Yilong
$PROB ALL_MET
$INPUT ID AMT TIME DV MET
$DATA ..\all_met.csv
$SUBROUTINES ADVAN6 TOL=3
$MODEL COMP=(DEPOT,INITIALOFF,DEFDOSE) COMP=(CENTRAL,DEFOBS,NOOFF) COMP=(EFFECT)
$PK
CALLFL=1
KA=THETA(1)*(1+ETA(1))
KE=THETA(2)*(1+ETA(2))
KM=THETA(3)*(1+ETA(3))
KEM=THETA(4)*(1+ETA(4))
CL=THETA(5)*(1+ETA(5))
S2=CL/(KE+KM)
$THETA(0,1)(0,0.04)(0,0.04)(0,0.03)(0,10)
$OMEGA 0.5 0.5 0.5 0.5 0.5
$DES
DADT(1)=-KA*A(1)
DADT(2)=KA*A(1)-(KE+KM)*A(2)
DADT(3)=KM*A(2)-KEM*MET*(CL/(KE+KM))
$ERROR
Y=F*(1+EPS(1))
$SIGMA 0.5
$ESTIMATION MAXEVAL=999 PRINT=5 POSTHOC
$COVARIANCE
$SCATTER TIME VS DV
$SCATTER TIME VS PRED
$SCATTER TIME VS RES
$SCATTER PRED VS DV UNIT
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