Re: LLR test, AIC, BIC

From: Nick Holford n.holford@auckland.ac.nz Subject: Re: [NMusers] LLR test, AIC, BIC Date: 10/22/2003 7:39 PM Leonid, The simulation form of the randomization test can be made as crude as you wish to meet your own correctness criterion "with the highest probability that crude criteria will correctly approximate true distribution". The crudity (or precision) is determined simply by the number of replications. I am not advocating that the RT be used at every stage of model building. A 10 point change in LLR for one parameter using FOCE along with other diagnostic info is a practical approach while learning about a drug. But when the focus of the drug development modelling is to support a confirming rather than a learning focus then attention should be paid to the assumptions made when doing hypothesis testing. BTW I cannot agree with your generalization "even with the most advanced hardware/software combination you will not be able to apply this procedure ...". As other recent posts to nmusers have indicated it is quite *possible* to apply the procedure to many problems but I would not consider it an effective use of time and resources for model building. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/