Re: Adaptive trial simulations using NONMEM
From:
Subject:Re: [NMusers] Adaptive trial simulations using NONMEM
Date:Tue, 8 Apr 2003 14:01:33 -0400
We have done some of this by giving a dose of 1.0 (in the data set) at any time you might give
a dose for any dosing regimen, then adjusting the dose (including setting dose = 0) by change
F programmatically. e.g.,
PD is pharmacodynamic endpoint.
if (PD.LE.10) THEN
F1 = 500
ELSE
F1 = 0
ENDIF
could use values other than 500 to get other doses.
For your case, you may need to put some indicator variables in the data set to say whether this
is week 1 or 2 for the every other week, e.g.,
# ID TIME AMT DV WEEK)
1 0 1 . 0
1 168 1 . 1
1 336 1 . 2
1 504 1 . 3
Then
IF (PD.LE.10.AND.(WEEK.EQ.0.OR.WEEK.EQ.2)) THEN
F1 = 500
ELSE
F1 = 0
ENDIF
Mark
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