Re: Adaptive trial simulations using NONMEM

From: "Ekaterina Gibiansky" Subject: Re: [NMusers] Adaptive trial simulations using NONMEM Date:Tue, 08 Apr 2003 12:02:50 -0400 Balaji, one way, probably not the most efficient though, is to do simulation in steps. Run your simulation with dummy line for dosing once a week first, having for example EVID=2 on those lines to get predictions at that times. From the simulated marker, figure out when dosing should start for each patient. Create the second data file where AMT are not all zeros any more, but correspond to the doses you want to give. Run simulation again using the SAME seed you had in the first run. That way the generated sequence of random values will be the same, so you'll get the same etas and epsilons as in the first run. Katya Ekaterina Gibiansky, PhD Head, Pharmacometrics & Principal Scientist Guilford Pharmaceuticals Inc Phone: (410)-631-6828 Fax: (410)-631-6828 E-mail: gibianskye@guilfordpharm.com