Adaptive trial simulations using NONMEM

From:"Agoram, Balaji" Subject: [NMusers] Adaptive trial simulations using NONMEM Date: Mon, 7 Apr 2003 19:01:17 -0700 All I am trying to run an adaptive trial simulation using NONMEM and I am not sure how to proceed. Specifically, I am simulating my PD marker which starts at a baseline H0 and decreases according to a first order equation, and when it reaches a threshold Ht, I would like to start dosing my drug at a certain frequency. The marker is measured every two weeks and I would like to explore dosing frequencies of qW, q2W, and q4W. It is possible that in some cases H0<Ht in which case I would like to start dosing at the start itself. Any idea on how to organize my control stream and input data stream would be tremendously helpful. Regards Balaji Agoram, Ph.D. PKDM, Amgen, Inc. MS30E-0-A Thousand Oaks, CA 91320