RE: large CV

From:"Howard Lee" Subject: RE: [NMusers] large CV Date: Wed, 5 Mar 2003 09:23:15 -0500 Dear Luciane, You modeled `additive' interindividual variability for V2 as the following: TV2=THETA(2) V2=TV2+ETA(2) Therefore, SQRT(OMEGA(V2)) is SD, and your CV (%) is [SD/THETA(2)]*100 = [SQRT(OMEGA(V2))/THETA(2)]*100, which I think will give you smaller CV for V2. Hope this helps. Thank you. Howard Howard Lee, MD, PhD Assistant Professor Center for Drug Development Science Department of Pharmacology, Georgetown University School of Medicine, Box 571441 Washington, DC 20057-1441 USA Tel: 202-687-8198 Fax: 202-687-0193