RE: large CV

From:"Bachman, William" Subject:RE: [NMusers] large CV Date:Wed, 5 Mar 2003 08:50:21 -0500 A couple of possibilities: 1. interindividual variability in V2 may actually be large 2. you might not have the information in your data to determine the interindividual variability in V2 (interindividual variability in the peripheral parameters is often poorly determined, you may want to omit the eta's on V2 and Q) 3. with dense data and high variability, use of FOCE method is recommended (METHOD=1) 4. also, use INTERACTION with METHOD=1 if possible 5. unless you have observations in the peripheral compartment, you don't need S3=V3 (but won't have an effect on your model if you leave it in). William J. Bachman, Ph.D. GloboMax LLC 7250 Parkway Drive, Suite 430 Hanover, MD 21076 410-782-2212 bachmanw@globomax.com