NONMEM Tips #13 - August 26, 2002 - New Windows and UNIX Releases of Xpose available

From:"Bachman, William" Subject: [NMusers] NONMEM Tips #13 - August 26, 2002 - New Windows and UNIX Releases of Xpose available Date:Mon, 26 Aug 2002 14:18:16 -0400 New releases of Xpose (version 3.011) have been made available from the University of Uppsala: http://www.biof.uu.se/Xpose/index.html Xpose is an S-PLUS based model building aid for population analysis using NONMEM. It facilitates data set checkout, exploration and visualization, model diagnostics, candidate covariate identification and model comparison: * Data set checkout includes visualization of the observed variable(s), covariates and plots to reveal errors in the data file. * Model diagnostic plots includes the usual residual plots but also plots to check the validity of assumptions specific to non-linear mixed effects models. * Data exploration is also done by various plots but also includes auxiliary screening analyses such as stepwise generalized additive modeling (GAM) and tree based modeling. * The stability of the GAM results with respect to covariate model selection as well as the impact of influential individuals and certain types of covariate interactions can be explored using a bootstrap re-sampling procedure. * To facilitate documentation, Xpose can produce run summaries and run records. The run records are one page summaries of a run consisting of a combination of goodness of fit plots, parameter estimates and the model file. Run records are tabulated summaries of many runs consisting of user comments, termination messages and objective function values. Changes in latest Xpose 3 versions: Xpose 3.010 -> Xpose 3.011 * Fixed the "quit-problem". Xpose 3.009 -> Xpose 3.010 * All PRED vs DV plots are changed to DV vs PRED, which is actually the right way of drawing these graphs! * Run records can now be exported as HTML-tables that can be directly imported into MS Word. * Changed the contents of the distribution a bit. * Minor bugfixes. Put back one of the functions that creates a time after dose data item (it disappeared between 3.008 and 3.009). Reference: E. N. Jonsson and M. O. Karlsson - "Xpose - an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM", Comp Meth Prog Biomed 58 (1999), pp: 51-64. Previous tips may be found in the NONMEM Repository@GloboMax: ftp://ftp.globomaxnm.com/Public/nonmem/tips/ See the index.txt file for a listing of previous tips. *************************************************************************** If you have a "tip" or a better way to do things, by all means, feel free to post them! One of the reasons for doing this (other than good PR for GloboMax), is to stimulate discussion. We at GloboMax can learn from your experience as well. Do you have a "tip" you would like to share, but would prefer to remain anonymous? If so, you may forward it to us and your identity will be withheld. Distribution as a "Tip of the Week" will be at the discretion of nmconsult@globomaxnm.com. *************************************************************************** nmconsult@globomaxnm.com GloboMax LLC 7250 Parkway Drive, Suite 430 Hanover, MD 21076 Voice: (410) 782-2205 FAX: (410) 712-0737