Sensitivity analysis

From:Paul Hutson Subject:[NMusers] Sensitivity analysis Date:Thu, 05 Sep 2002 13:50:40 -0500 Hello, everyone. Has anyone suggestions on how to perform a sensitivity analysis (if one is possible) when using MAXEVALS=0 to perform a "Bayesian" fit of new data using prior reports of PK parameters as the respective initial estimates of $THETA ? Other than tweaking the OMEGAs to see the impact on new THETA estimates, there doesn't seem to be much left to alter. It also would seem to me that using the minimization of the objective function for a MAXEVAL=0 run would potentially be misleading in interpreting the optimality of the resulting THETAs. Could use the appearance of the residual plots, I suppose... What advice do you have? Thanks Paul Paul Hutson, Pharm.D. Associate Professor (CHS) UW School of Pharmacy 777 Highland Avenue Madison, WI 53705-2222 Tel: (608) 263-2496 FAX: (608) 265-5421 Pager: (608) 265-7000, #7856