Wrong model

From:"Bonate, Peter" Subject:[NMusers] Wrong model Date:Fri, 12 Jul 2002 11:07:15 -0500 Hi, everyone. Its generally recognized that with sparse data from a Phase III study we often need to fit a simpler compartmental model than the one that could be obtained from rich Phase I data, e.g., 1-compartment with sparse data but 2-compartment with rich data. Can someone point me to some references that examine what impact this simplification has on the estimates of the common pk parameters. For example, how biased is clearance or central volume. Thanks alot. pete Peter L. Bonate, PhD Director, Pharmacokinetics ILEX Oncology, Inc 4545 Horizon Hill Blvd San Antonio, TX 78229 phone: 210-949-8662 fax: 210-949-8487 email: pbonate@ilexonc.com