RE: sequential PK/PD

From: Sriram.Krishnaswami@aventis.com Subject: RE: [NMusers] sequential PK/PD Date: Wed, 1 May 2002 19:37:52 -0500 Liping, thanks for the clarification. However, my question was slightly different. I was only intending to use individual PK parameter estimates for PD fitting and while doing so, I was interested to know if retaining the observed concentrations in the data file would make any difference to the results at all? In other words, when you use individual predicted CL and V from the PK fit from step 1 to fit PD data in step 2, why do you still need PK DV to be present in the data file? or dont we? I am not sure if and how the objective function and other diagnostics etc would be affected by not having the PK DV. hence the question. thanks Sriram