RE: Capturing AUC between observation time intervals

From: "Hu, Chuanpu" Subject: RE: [NMusers] Capturing AUC between observation time intervals Date: Wed, 3 Apr 2002 17:02:15 -0500 Leonid/Sam, I guess my original message was not clear. Say that I have time points T1=0, T2, T3, ... I would like to do keep AUC(T1, T2), AUC(T2,T3), etc., during NONME fit. That is, I want to simutaneously fit PK (which drives the AUCs) and the PD parameters to fit the PD endpoint. Via eauation dAUC/dt=C I can compute the cumulative AUC, but somehow a variable needs to be created to memorize the cumulative AUC at the previous time. I do not see how the suggested approaches could be used. Am I missing something? Chuanpu