"Tip of the Week #6 - April 3, 2002" - Current contents of the NO NMEM Repository @

From: "Bachman, William" Subject: [NMusers] "Tip of the Week #6 - April 3, 2002" - Current contents of the NO NMEM Repository @ GloboMax Date: Wed, 3 Apr 2002 10:38:50 -0500 This week's tip is a reminder of what is currently available in the NONMEM Repository @ GloboMax: Welcome to the NONMEM Repository @ GloboMax LLC. ftp://ftp.globomaxnm.com/Public/nonmem/ (Formerly hosted at the Palo Alto VA and Stanford University). ---------------------------------------------------------------------------- ---- This repository does not contain the NONMEM program source code (except for user- supplied routines, e.g. PRED routines, written by individual NONMEM users). The NONMEM source code is copyrighted by the Regents of the University of of California. Individuals desiring to license NONMEM program source code should contact: nminfo@globomaxnm.com ---------------------------------------------------------------------------- ---- The repository is organized by directories. The current directories are listed in the index below. We encourage the repository to be used to share user-supplied NONMEM codes, NONMEM data sets of interest, NM-TRAN control streams, frontend and backend programs to the NONMEM system, and the like. One might, for example, contribute NONMEM files (except possibly proprietary data) used to implement a particular application of interest e.g. an analysis of both the PK and PD data from a study of brain-wave activity with the administration of thiopental. Please feel free to browse through the repository. The repository is read-only. We would very much appreciate your contributing files to the repository. Please forward your files to nmconsult@globomaxnm.com and we'll make them available on the ftp server. Presence of any file on the ftp server does not imply endorsement of it's use by GloboMax LLC. Suitability of any file for use is determined by the individual user and is the responsibility of the individual user. The NONMEM repository is maintained by GloboMax LLC and is independent of the NONMEM Project Group. In addition to new materials, the repository contains material originally maintained by Steve Shafer and Jaap Mandema while at the Stanford University Department of Anesthesia. Thank you for your interest in the NONMEM respository. We hope you will use this repository to share with others your work with NONMEM. INDEX _____ Compliance: NONMEM codes for a Markov model for drug compliance contributed by Pascal Girard, Lewis B Sheiner (pg@upcl.univ-lyon1.fr, lbs@c255.ucsf.edu) Compliance2: MIXTURE MODEL FOR ASSIGNING RELIABILITY TO PK OBSERVATIONS AND ESTIMATING INDIVIDUAL PK PARAMETERS Continuous&cateogorical: Simultaneous continuous and cateogorical modelling contributed by Nick Holford (n.holford@auckland.ac.nz) Discussions: Notes on Concentrations below the limits of detection Help.Dos.Tools: The files in this directory comprise the disk labelled "NONMEM Help Guide - DOS tools - May 1996" This disk is distributed along with NONMEM Guide VIII. Hf0304.dir: This directory contains a single file, hf0304.zip. This file is the patch required in Microsoft Fortran 5.1 to open more than 25 files simultaneously, as required for NONMEM. ***OBSOLETE COMPILER*** JWM: This directory contains NONMEM control files for various applications (NONMEM IV) 1. Models for categorical data applied to analgesia data 2. PRED routines for 3-compartment models with multiple drug infusions contributed by Jaap W Mandema Michaelis-Menten: control stream for a two compartment model with parallel first order elimination and Michaelis- Menten elimination. For straight MM just remove the linear contribution. contributed by Bill Bachman (bachmanw@globomax.com ) NMREPORT: a VMS procedure (together with a couple of FORTRAN programs) that run sequences of NONMEM jobs, computes AIC and SBC criteria for model comparisons, creates one output file for all the models. !!! It will work ONLY with VMS !!! contributed by Ekaterina Gibiansky NMSEE: a post-processor program for NONMEM output. Nmsee extracts important lines from the NONMEM output. It can be instructed to ignore certain lines, to reformat them, and to precede them with identifying prefixes. It has been revised for NONMEM V. contributed by Alison Boeckmann NMVCL: A PRED for 1,2, and 3 compartment mammillary pharmacokinetic models in terms of volumes and clearance. Covariates are entered into the model by use of an external table that relates thetas and covariates to the individual volume and clearance terms. contributed by Steve Shafer NON_CONTINUOUS: Meant to contain control files for non-contiuous type data such as counts, proportions, time-to-event, categorical. Currently contains control files for time-to-event and (binary) categorical. contributed by Lewis Sheiner (lbs@c255.ucsf.edu) TIPS: NONMEM Tips of the Week contributed by GloboMax LLC (nmsupport@globomaxnm.com) Output: NONMEM output files obtained using: 1. NONMEM V Level 1.1 2. Compaq Visual Fortran Optimizing Compiler Version 6.6 (/optimize:1 /fpe:0) 3. Dell Precision 420 Pentium III 4. Windows NT 4.0 SP 6 5. control3-control7 files from the NONMEM distribution contributed by nmconsult@globomaxnm.com PKPD: Various control streams that implement PK/PD modeling (with tolerance). contributed by Lewis Sheiner (lbs@c255.ucsf.edu) SGI_TIPS: A summary of SGI R10000 processor capabilities and the recommended compile options and buffer dimensions. contributed by Tom Elken VMS_TIPS: OpenVMS command procedures for NONMEM IV contributed by Brian M. Sadler ***************************************************************** If you have a "tip" or a better way to do things, by all means, feel free to post them! One of the reasons for doing this (other than good PR for GloboMax), is to stimulate discussion. We at GloboMax can learn from your experience as well. Do you have a "tip" you would like to share, but would prefer to remain anonymous? If so, you may forward it to us and your identity will be withheld. Distribution as a "Tip of the Week" will be at the discretion of nmconsult@globomaxnm.com. ***************************************************************** nmconsult@globomaxnm.com GloboMax LLC 7250 Parkway Drive, Suite 430 Hanover, MD 21076 Voice: (410) 782-2205 FAX: (410) 712-0737