Calculation of AUC for multiple oral doses

From:"Sreenivasa Rao Vanapalli" Subject:[NMusers] Calculation of AUC for multiple oral doses Date:Tue, February 19, 2002 8:40 pm Hi, I have a question regrading AUC calculation for a multiple oral dose for 28 days. The oral dose was administered daily for 28 days in rats. But the dose was adjusted for animal body weight every week. So the dose has been changing during the 28 days period. I want to calculate AUC for 28 days in each animal. Is there any code that can be used to calculate AUC for 28 days? Thanks Sreenivasa Rao Vanapalli, Ph.D. University of Iowa Iowa City