RE: Modeling of Blood flow data

From:"Sam Liao" Subject:RE: [NMusers] Modeling of Blood flow data Date: Tue, February 19, 2002 6:15 pm Hi Partha: I am not sure how to tell that the rate of absorption is blood flow dependent. I expect the rate-limiting step is the skin-permeation rather than the blood flow. But, if you want to incorporate the blood flow (BFLW) in your model, I would suggest to use ADVAN8 and define your model in differntial equations as follow, good luck! =============================================== $SUBROUTINES ADVAN8 TOL=6 $MODEL NCOMP=2 COMP=(ABS) COMP=(CENTRAL) $PK TVKA = THETA1(1)*BFLW/(THETA(2)*BFLW) CL = THETA(3)*EXP(ETA(1)) V = THETA(4)*EXP(ETA(2)) KA = TVKA*EXP(ETA(3)) S2=V $DES DADT(1)=-KA*A(1) DADT(2)= KA*A(1)-CL/V*A(2) =============================================== Best regards, Sam Liao, Ph.D. PharMax Research 270 Kerry Lane, Blue Bell, PA 19422 phone: 215-6541151 efax: 1-720-2946783