RE: Calculation of AUC for multiple oral doses
From:"Sam Liao"
Subject: RE: [NMusers] Calculation of AUC for multiple oral doses
Date:Tue, February 19, 2002 9:59 pm
Hi Sreenivasa:
You can use NONMEM to calculate the pre-dose concentration (CMIN) for each
day. Then use a do loop with the following codes to calculate the daily AUC
and cumulative AUC out site of NONMEM (I used SAS code). It is based on the
superposition theory, Cmin1 is the concentration 24-hr post a single dose.
It is based on a one-compartment model.
=============================================================
CMIN1= DOSE*KA/(V*(KA-KEL))*(EXP(-KEL*24) - EXP(-KA*24));
AUC24= DOSE/CL - CMIN1/KEL + CMIN*(1 -EXP(-KEL*24))/KEL;
CUMAUC=CUMAUC+AUC24;
=============================================================
Best regards,
Sam Liao, Ph.D.
PharMax Research
270 Kerry Lane,
Blue Bell, PA 19422
phone: 215-6541151
efax: 1-720-2946783